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KMID : 1123920110250050919
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 5 p.919 ~ p.926
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Domestic review of Korean medical treatment on Carbon Tetrachloride-induced Hepatotoxicity - Focusing on Treatment of Korean Herbal Medicine
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Kim Na-Hyeon
Kim Soo-Il
Shin Min-Kyu
Kim Jin-ju
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Abstract
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The purpose of this study is to inspect trends of the paper of Korean medical treatment on Carbon Tetrachloride-induced Hepatotoxicity and try to establish the future direction for development of Korean herbal medicine. We reviewed 79 papers which had been published from 1981 to 2010 in journals published in Korea. According to these studies, Carbon Tetrachloride-induced hepato-celluar degeneration and necrosis induced to increase in serum aspartate amintransferase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP), ?-Glutamyl transferase (?-GTP), lactate dehydrogenase (LDH), bilirubin, blood urea nitrogen (BUN) and albumin levels. In biochemical analyses, antioxidant enzymes such as superoxide dismutase (SOD), Glutathione S-transferase (GST) and catalase in hepatic tissue were remarkably incresed by Carbon Tetrachloride treatment. We found that some of the herbal extracts have a protective effect against Carbon Tetrachloride-induced Hepatotoxicity. More studies of oriental medicinal herbs are required for developing a treatment of hepatotoxicity.
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KEYWORD
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hepatotoxicity, Korean herbal medicines, carbon tetrachloride, liver
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